Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function
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متن کاملSchwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function.
Mitochondrial dysfunction is a common cause of peripheral neuropathies. While the role of neuron and axonal mitochondria in peripheral nerve disease is well appreciated, whether Schwann cell (SC) mitochondrial deficits contribute to peripheral neuropathies is unclear. Here, we examine how SC mitochondrial dysfunction affects axonal survival and contributes to the decline of peripheral nerve fun...
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Andreu Viader,1 Judith P. Golden,2 Robert H. Baloh,3,5 Robert E. Schmidt,4,5 Daniel A. Hunter,6 and Jeffrey Milbrandt1,5 1Department of Genetics, 2Pain Center and Department of Anesthesiology, 3Department of Neurology, 4Department of Pathology, 5Hope Center for Neurological Disorders, and 6Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Misso...
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The role of mitochondrial biogenesis in hair cell survival after injury was evaluated by inhibiting mitochondrial protein synthesis with chloramphenicol and then studying the effects on hair cell survival after exposure to two different types of ototoxins, gentamicin and acoustic trauma. Seven- to 10-day-old chicks were treated with either a single injection of gentamicin (250 mg/kg) or noise (...
متن کاملRadioimmunoassay for pregnancy-associated plasma protein A.
A specific and highly sensitive radioimmunoassay for determination of pregnancy-associated plasma protein A in human serum is described. The minimum detection limit for this protein was 2.9 micrograms/L. The within- and between-assay coefficients of variation were 4.0 and 4.5%, respectively. The circulating protein was detected within 32 days of conception in eight normal pregnancies and within...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.47061